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Impaired gonadal function following chemotherapy and radiotherapy in childhood and adolescence: risks, diagnosis, prophylaxis and treatment options.

This guideline addresses patients who— due to pediatric oncologic disease—will receive or have received surgery or radiation therapy to the hypothalamus, pituitary, or pelvis as well as chemotherapy during childhood or adolescence. In addition to presenting the risk factors for possible hypogonadism or impaired fertility, diagnosis, as well as established and experimental prophylactic and treatmentmeasures are also introduced.

The guideline was developed by the Working Group "Fertility" of the Society for Pediatric Oncology and Hematology (GPOH), in collaboration with other professional societies.

Link to AWMF S1-Guideline: Impairment of gonadal function after chemo- and radiotherapy during childhood and adolescence

Link to AWMF S2k-Guideline: Fertility preservation during oncological therapies



Information about the AWMF

The AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.) currently unites 158 scientific societies from all fields of medicine. All guidelines are regularly reviewed and updated by the member societies.

To the AWMF

International guidelines

In addition to the recommendations in German-speaking countries for fertility following childhood and adolescent cancer, we have also listed links to international guidelines.

Link  to international recomandations(1) 

Link international recomandations (2)