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FeCt, fertility after allogeneic stem cell transplantation 2009
For this study data concerning the fertility of allogeneic transplanted patients were collected in seven European centres in Germany, Austria and the Czech Republic. The incidence of fertility impairment and the correlating risk factors were detected for 138 women and 206 men, who underwent stem cell transplantation between 2000 and 2005.
In 83% of the women and 69% of the men, signs of fertility impairment were found. Significant risk factors for fertility impairment were, regarding women, start of treatment at age ≥13 years and a treatment with busulfan. Regarding men a pre-pubertal age at start of treatment and a total body irradiation correlated with an increased risk for fertility impairment.
Link to the article: http://www.nature.com/bmt/journal/vaop/ncurrent/full/bmt201178a.html