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FeCt, Berlin hormone/sperm analysis 2009
To validate the results of the previous surveys, we carried out a study in Berlin on 'FeCt, hormone analyses and spermiograms' in which hormone and sperm analyses were carried out in former pediatric oncology patients.
A total of 748 former pediatric oncology patients in Berlin who were adults at the time of the survey were contacted. The participants' serum samples were analyzed in the Department of Gynecology at Erlangen University Hospital. In addition to the standard parameters for fertility diagnosis (FSH, LH, estrogen, testosterone, progesterone, prolactin, SHBG, and DHS), more recent markers such as inhibin B in male participants and antimüllerian hormone (AMH) in female participants were assessed. The sperm analyses were carried out in the Department of Dermatology at the Charité Hospital.
We received 159 blood samples from 86 women and 73 men. Forty-two of the male participants took part in the sperm analysis. The average age of the participants was 25. In 14 of the 86 female participants (16%), AMH values < 0.1 ng/mL were measured. Follicular reserve appears to be severely limited in these participants, increasing the risk of infertility. Twenty-one female participants (24%) had AMH values between 0.1 and 1.0 ng/mL, with a suspicion of imminent ovarian failure with limited follicular reserve.
Inhibin B values < 80 pg/mL were found in 23 of the 73 male participants (32%), in combination with FSH values > 10 IU/L, which may suggest infertility. Thirteen of the 42 spermiogram findings (31%) showed azoospermia.
Four percent of the female participants in the national questionnaire survey stated that they had permanent amenorrhea. Contrasting this with the 16% of participants in the hormone analysis who had suspected infertility, it can be assumed that several female participants only had menstruation as a result of using contraceptives.
For persons who wish to have own children after undergoing therapy, we recommend a hormone and sperm analysis. An early analysis may enable a more successful family planning. Addresses of specialized fertility clinics in Germany can be obtained, e.g., at: www.fertiprotekt.de.
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